BDBM436993 (1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4'-((2R,4R)-2-(hydroxymethyl)-4-methylazetidin-1-yl)-4-methyl-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 640a

SMILES C[C@@H]1C[C@H](CO)N1c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CO[C@@]1(CC[C@H](C)c3ccc(N)c(C#N)c31)C2

InChI Key InChIKey=CQAVGXILPOPRIZ-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 436993   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436993BDBM436993((1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1...)
Affinity DataKd:  0.0910nMAssay Description:Table B2: Biacore 8K buffer line was placed into 1 L of Immobilization buffer (20 mM HEPES pH 7.5/150 mM NaCl/5 mM MgCl2/0.5 mM TCEP/0.005% P20/500 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436993BDBM436993((1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1...)
Affinity DataIC50: 2.5nMAssay Description:Table B1: KRas G12V: Compounds were pre-dispensed via Echo liquid handling (acoustic, touch-free) to generate assay ready plates (ARP). More precisel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent