BDBM437992 US10597387, Compound (I-8)

SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(NC(=O)c4cncc(c4)-c4cnoc4)c3)cc2C(F)(F)F)CC1

InChI Key InChIKey=KTULYYQYBLJWBV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 437992   

TargetTyrosine-protein kinase HCK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM437992(US10597387, Compound (I-8))
Affinity DataIC50: 5.33nMAssay Description:The in vitro activity of the compounds described herein in inhibiting TAK1, HCK, and other kinases were obtained using an Invitrogen Select Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM437992(US10597387, Compound (I-8))
Affinity DataIC50: 69.7nMAssay Description:The in vitro activity of the compounds described herein in inhibiting TAK1, HCK, and other kinases were obtained using an Invitrogen Select Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent