BDBM438354 N-(4-fluorophenyl)-2-methyl-5-((2-methyl- thiazol-4-yl)ethynyl)benzamide::US10618900, No. ZD041

SMILES Cc1nc(cs1)C#Cc1ccc(C)c(c1)C(=O)Nc1ccc(F)cc1

InChI Key InChIKey=OPCHQVXFRMFNPU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 438354   

TargetMetabotropic glutamate receptor 5(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438354(N-(4-fluorophenyl)-2-methyl-5-((2-methyl- thiazol-...)
Affinity DataIC50: 1.09E+5nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent