BDBM438362 (2-fluoro-5-((2-methyl-thiazol-4-yl) ethynyl)phenyl)(1-methyl-3,4-dihydro- isoquinolin-2(1H)-yl)methanone::US10618900, No. ZD049

SMILES CC1N(CCc2ccccc12)C(=O)c1cc(ccc1F)C#Cc1csc(C)n1

InChI Key InChIKey=MRFFFEPDDIRFHJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 438362   

TargetMetabotropic glutamate receptor 5(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438362((2-fluoro-5-((2-methyl-thiazol-4-yl) ethynyl)pheny...)
Affinity DataIC50: 3.80E+4nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438362((2-fluoro-5-((2-methyl-thiazol-4-yl) ethynyl)pheny...)
Affinity DataIC50: 3.80E+4nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438362((2-fluoro-5-((2-methyl-thiazol-4-yl) ethynyl)pheny...)
Affinity DataIC50: 1.00E+5nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent