BDBM438367 3-((2-methylthiazol-4-ylethynyl)-N- (pyridin-3-yl)benzamide::US10618900, No. ZD013

SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1cccnc1

InChI Key InChIKey=FCZOCWZZOBYIHR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 438367   

TargetMetabotropic glutamate receptor 5(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438367(3-((2-methylthiazol-4-ylethynyl)-N- (pyridin-3-yl)...)
Affinity DataIC50: 1.42E+4nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438367(3-((2-methylthiazol-4-ylethynyl)-N- (pyridin-3-yl)...)
Affinity DataIC50: 1.42E+4nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438367(3-((2-methylthiazol-4-ylethynyl)-N- (pyridin-3-yl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent