BDBM438373 3-((2-methylthiazol-4-ylethynyl)-N-(4- (trifluoromethyl)phenyl)benzamide::US10618900, No. ZD015

SMILES Cc1nc(cs1)C#Cc1cccc(c1)C(=O)Nc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=FLGBIOCDQABTQW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 438373   

TargetMetabotropic glutamate receptor 5(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438373(3-((2-methylthiazol-4-ylethynyl)-N-(4- (trifluorom...)
Affinity DataIC50: 2.92E+4nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM438373(3-((2-methylthiazol-4-ylethynyl)-N-(4- (trifluorom...)
Affinity DataIC50: 1.00E+5nMAssay Description:Experimental material: HEK293/mGluR5 cell line, Fluo-8 calcium ion fluorescent dye, positive control MPEP, CTEPExperimental instrument: FLIPR Tetra r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent