BDBM438727 N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]piperidin-4-yl}-N- methylacetamide::US10618910, Example 6

SMILES CC(=O)N(C)C1CCN(c2nc3ccc(-c4c(C)noc4C)c4c3n2[C@@H](c2ccccn2)CO4)CC1

InChI Key InChIKey=KQJJFAFXMLVFRW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 438727   

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 438727BDBM438727(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridi...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 438727BDBM438727(N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridi...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent