BDBM438730 (4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[(3S)- 4-isobutyryl-3-methylpiperazin-1-yl]-4- pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazine::US10618910, Example 9

SMILES Cc1noc(C)c1-c1ccc2nc(N3CCN(C(=O)C(C)C)[C@H](C)C3)n3c2c1OC[C@@H]3c1ccccn1

InChI Key InChIKey=QVFNWZZKUKTJTE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 438730   

TargetBromodomain-containing protein 4 [49-170](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 438730BDBM438730((4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[(3S)- 4-isob...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 438730BDBM438730((4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[(3S)- 4-isob...)
Affinity DataIC50: 25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent