BDBM439270 (S)-5-fluoro-2,3-dimethyl-4-(3-(vinylsulfonamido)piperidin-1-yl)-1H-indole-7-carboxamide::US10604504, Example 146

SMILES Cc1[nH]c2c(cc(F)c(N3CCC(CC3)NS(=O)(=O)C=C)c2c1C)C(N)=O

InChI Key InChIKey=AQQKDKSQTYRGAE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 439270   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM439270((S)-5-fluoro-2,3-dimethyl-4-(3-(vinylsulfonamido)p...)
Affinity DataIC50: 0.200nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent