BDBM439612 1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(2-fluoro-3-methoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[2,1-f][1,2,4]triazin-6-yl)phenyl)-3-methylurea::US10633388, Example 14

SMILES CNC(=O)Nc1ccc(cc1)-c1cn2n(Cc3c(F)cccc3F)c(=O)n(-c3cccc(OC)c3F)c(=O)c2c1CN(C)C

InChI Key InChIKey=ARRSLJSZDGPQCC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 439612   

TargetGonadotropin-releasing hormone receptor(Human)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM439612(1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)met...)
Affinity DataIC50: 0.110nMAssay Description:In vitro GnRHr protein activity was tested by the following methods.This assay was used to determine the inhibition effect of the present compound on...More data for this Ligand-Target Pair
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Date in BDB:
1/10/2021
Entry Details
US Patent