BDBM439715 US10633389, Example 23-1a::US10633389, Example 24-1a::US20230279020, Example 24-1a

SMILES CNCC(O)COc1cccc(c1)-c1nc(NC2CCOC2=O)cc(n1)-c1c(C)noc1C

InChI Key InChIKey=IBTAITHEHCFGDV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 439715   

TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM439715(US10633389, Example 24-1a | US10633389, Example 23...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM439715(US10633389, Example 24-1a | US10633389, Example 23...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent

TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM439715(US10633389, Example 24-1a | US10633389, Example 23...)
Affinity DataIC50: 550nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM439715(US10633389, Example 24-1a | US10633389, Example 23...)
Affinity DataIC50: 550nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent