BDBM442468 US10647713, Compound I-429::US11396508, Compound I-429

SMILES Cn1ccc(n1)-c1ccc(Nc2cc(NC(=O)C3CC3)nc3[nH]c(nc23)C(F)F)c(c1)P(C)(C)=O

InChI Key InChIKey=CLLHUJBETCALEX-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442468   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM442468(US10647713, Compound I-429 | US11396508, Compound ...)
Affinity DataKd: <0.100nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM442468(US10647713, Compound I-429 | US11396508, Compound ...)
Affinity DataKd: <1.00E+5nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
US Patent