BDBM442772 1-Methyl-4-{1-[4-(trifluoromethyl)phenyl]cyclopropylamino}-1H-pyrazolo[3,4-d]pyrimidine-6-carbonitrile::US10647727, Example 29

SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(nc12)C#N

InChI Key InChIKey=YZFLKZURCKIMOP-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442772   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442772(US10647727, Example 29 | 1-Methyl-4-{1-[4-(trifluo...)
Affinity DataKi:  39nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442772(US10647727, Example 29 | 1-Methyl-4-{1-[4-(trifluo...)
Affinity DataKi:  47nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent