BDBM442832 US10647720, Ex. # 91

SMILES OC(=O)CC1CCC(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1

InChI Key InChIKey=OILJTSQUFHFIEV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442832   

TargetTyrosine-protein kinase SYK(Human)
Asan Biosciences

US Patent
LigandPNGBDBM442832(US10647720, Ex. # 91)
Affinity DataIC50: 10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Asan Biosciences

US Patent
LigandPNGBDBM442832(US10647720, Ex. # 91)
Affinity DataIC50: 30nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent