BDBM442844 US10647720, Ex. # 103::US10647720, Ex. # 114

SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(nc3)N3CCC(CC#N)CC3)c12)N1CCC(CC#N)CC1

InChI Key InChIKey=BDIYBAQRVGMTLJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 442844   

TargetTyrosine-protein kinase SYK(Human)
Asan Biosciences

US Patent
LigandPNGBDBM442844(US10647720, Ex. # 114 | US10647720, Ex. # 103)
Affinity DataIC50: 10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Asan Biosciences

US Patent
LigandPNGBDBM442844(US10647720, Ex. # 114 | US10647720, Ex. # 103)
Affinity DataIC50: 10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Asan Biosciences

US Patent
LigandPNGBDBM442844(US10647720, Ex. # 114 | US10647720, Ex. # 103)
Affinity DataIC50: 10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Asan Biosciences

US Patent
LigandPNGBDBM442844(US10647720, Ex. # 114 | US10647720, Ex. # 103)
Affinity DataIC50: 30nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent