BDBM443434 US10654866, Example 2B::US11117902, Example 2A::US11634426, Example 2B

SMILES Oc1ccc2c3[C@@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1

InChI Key InChIKey=BGOOMSGEXIBXHQ-MHZLTWQESA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 443434   

TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443434(US10654866, Example 2B | US11117902, Example 2A | ...)
Affinity DataKi:  0.650nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443434(US10654866, Example 2B | US11117902, Example 2A | ...)
Affinity DataKi:  7.92nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443434(US10654866, Example 2B | US11117902, Example 2A | ...)
Affinity DataKi:  60.4nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443434(US10654866, Example 2B | US11117902, Example 2A | ...)
Affinity DataKi:  60.4nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443434(US10654866, Example 2B | US11117902, Example 2A | ...)
Affinity DataKi:  294nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443434(US10654866, Example 2B | US11117902, Example 2A | ...)
Affinity DataKi:  294nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent