BDBM444497 (S)-3-chloro-4-((1-(1-phenylethyl)piperidin-4-yl)oxy)-N-(thiazol-2-yl)benzenesulfonamide 2,2,2-trifluoroacetate::US10662184, Example 58::US10815229, Example 58::US11299490, Example 58

SMILES C[C@H](N1CCC(CC1)Oc1ccc(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1

InChI Key InChIKey=SUOIGKUVNXIDQA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 444497   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444497(US10662184, Example 58 | (S)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 93nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444497(US10662184, Example 58 | (S)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 93nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444497(US10662184, Example 58 | (S)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 93nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444497(US10662184, Example 58 | (S)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 402nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444497(US10662184, Example 58 | (S)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 5.14E+3nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444497(US10662184, Example 58 | (S)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 5.58E+3nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444497(US10662184, Example 58 | (S)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 9.15E+3nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444497(US10662184, Example 58 | (S)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 9.15E+3nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444497(US10662184, Example 58 | (S)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 9.15E+3nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent