BDBM444636 US10662187, Compound 6

SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCNC3)c3c(OC)cncc23)c1F

InChI Key InChIKey=XNJQHXBRQQSGDT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 444636   

TargetTyrosine-protein kinase BTK(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444636(US10662187, Compound 6)
Affinity DataIC50: 10nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444636(US10662187, Compound 6)
Affinity DataIC50: 10nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Blk(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444636(US10662187, Compound 6)
Affinity DataIC50: 55nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444636(US10662187, Compound 6)
Affinity DataIC50: 550nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Lyn(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444636(US10662187, Compound 6)
Affinity DataIC50: 5.50E+3nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Lck(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444636(US10662187, Compound 6)
Affinity DataIC50: 5.50E+3nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent