BDBM444696 ((R)-1-(3-(7-fluoro-3-(4-phenoxyphenyl)-1H- pyrazolo [4,3-c]pyridin-1-yl)pyrrolidin-1-yl)prop-2-en- 1-one::US10662187, Compound 66::US10793566, Compound 66

SMILES Fc1cncc2c(nn([C@@H]3CCN(C3)C(=O)C=C)c12)-c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=BKZIDKOLXDCCSF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444696   

TargetTyrosine-protein kinase BTK(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444696(US10662187, Compound 66 | ((R)-1-(3-(7-fluoro-3-(4...)
Affinity DataIC50: 10nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444696(US10662187, Compound 66 | ((R)-1-(3-(7-fluoro-3-(4...)
Affinity DataIC50: 10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent