BDBM444698 (R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)-7-fluoro-1H- pyrazolo [4,3-c]pyridin-1-yl)pyrrolidin-1-yl)prop-2-en- 1-one::US10662187, Compound 68::US10793566, Compound 68

SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3c(F)cncc23)c1Cl

InChI Key InChIKey=ABOWBBOLXCXZEL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444698   

TargetTyrosine-protein kinase BTK(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444698(US10662187, Compound 68 | (R)-1-(3-(3-(4-(2-chloro...)
Affinity DataIC50: 10nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444698(US10662187, Compound 68 | (R)-1-(3-(3-(4-(2-chloro...)
Affinity DataIC50: 10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent