BDBM444713 (R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)-7-propoxy- 1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-1- yl)prop-2-en-1-one::US10662187, Compound 83::US10793566, Compound 83

SMILES CCCOc1cncc2c(nn([C@@H]3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2Cl)cc1

InChI Key InChIKey=CJPQSTMRNJPTDW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444713   

TargetTyrosine-protein kinase BTK(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444713(US10662187, Compound 83 | (R)-1-(3-(3-(4-(2-chloro...)
Affinity DataIC50: 10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444713(US10662187, Compound 83 | (R)-1-(3-(3-(4-(2-chloro...)
Affinity DataIC50: 10nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
US Patent