BDBM4448 4-(3,4-Dimethoxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile::4-Anilino-3-cyanoquinoline deriv. 7e::4-[(3,4-dimethoxyphenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile::6,7-dialkoxyquinoline-3-carbonitrile deriv. 11

SMILES COc1ccc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)cc1OC

InChI Key InChIKey=PPNMPEHEXLGGID-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4448   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4448(4-Anilino-3-cyanoquinoline deriv. 7e | 4-[(3,4-dim...)
Affinity DataIC50: 950nMpH: 7.5 T: 2°CAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM4448(4-Anilino-3-cyanoquinoline deriv. 7e | 4-[(3,4-dim...)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM4448(4-Anilino-3-cyanoquinoline deriv. 7e | 4-[(3,4-dim...)
Affinity DataIC50: 5.05E+4nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed