BDBM444840 US10668094, Compound DcB-(cyclic)::US10668094, Compound DtxcB-(cyclic)::US11077128, Compound DcB

SMILES CC1CN(C2CCC2)CCC(O[C@@H]2[C@H](C)O[C@@H](O[C@@H]3[C@H](C)O[C@@H](O[C@H]4CC[C@@]5(C)C(CCC6C5C[C@H](O)[C@]5(C)[C@@H](C7=CC(=O)OC7)CC[C@]65O)C4)C[C@@H]3O)C[C@@H]2O)O1

InChI Key InChIKey=SBVAMPLOGURESG-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 444840   

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-3(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  4nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-3(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  4.30nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-2(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  5.30nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  5.40nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-2(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  6nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  8nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  8nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  30.7nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  135nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Human)
Yeda Research and Development

US Patent
LigandChemical structure of BindingDB Monomer ID 444840BDBM444840(US10668094, Compound DtxcB-(cyclic) | US10668094, ...)
Affinity DataKi:  135nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent