BDBM445363 US10682352, Compound 76::Using the same manner as in Example 1, Compound 76 was obtained from Intermediate A57 and Intermediate B8.

SMILES CC(C)[C@H]1CN(C)C(=O)N1c1ccnc(N[C@@H](C)c2cn(c(C)n2)-c2ccc(Cl)cc2)n1

InChI Key InChIKey=MMXIHHHILPTAKB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 445363   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM445363(Using the same manner as in Example 1, Compound 76...)
Affinity DataIC50: 100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
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Date in BDB:
2/15/2021
Entry Details
US Patent