BDBM445380 (5S)-1-(2-(((S)-1-(1-(4-trifluoromethylphenyl)-1H-imidazol-4-yl)ethyl)amino) pyrimidin-4-yl)-5-isopropyl-4-methylimidazolidine-2-one::US10682352, Compound 93

SMILES CC(C)[C@H]1[C@H](C)NC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)(F)F)n1

InChI Key InChIKey=GBRUPLLCLBJOHV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 445380   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM445380((5S)-1-(2-(((S)-1-(1-(4-trifluoromethylphenyl)-1H-...)
Affinity DataIC50: 100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent