BDBM445388 (S)-5-isopropyl-4,4-dimethyl-1-(2-(((S)-1-(1-(4-(trifluoromethyl)phenyl)-1H-imidazole)-4-yl)ethyl)amino)pyrimidin-4-yl)imidazolidine-2-one::US10682352, Compound 101

SMILES CC(C)[C@@H]1N(C(=O)NC1(C)C)c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)(F)F)n1

InChI Key InChIKey=MXFQZHAGPHDQJL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 445388   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM445388((S)-5-isopropyl-4,4-dimethyl-1-(2-(((S)-1-(1-(4-(t...)
Affinity DataIC50: 100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent