BDBM445401 (S)-1-(2-(((S)-1-(2′-(trifluoromethyl)-[3,4′-bipyridyl]-6-yl)ethyl)amino)-5, 5-dideutero-4-isopropyl-imidazolidine-2-one::US10682352, Compound 114::US10682352, Compound 115

SMILES CC(C)[C@H]1CNC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(F)(F)F)n1

InChI Key InChIKey=CPXJYTXMHUPWMN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 445401   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM445401(US10682352, Compound 115 | (S)-1-(2-(((S)-1-(2R...)
Affinity DataIC50: 100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM445401(US10682352, Compound 115 | (S)-1-(2-(((S)-1-(2R...)
Affinity DataIC50: 550nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent