BDBM445447 US10683279, Example 44a

SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(C)CC2)-n2cnc(c2)C2CC2)cs1

InChI Key InChIKey=YEARMHDKKLUQAZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 445447   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM445447(US10683279, Example 44a)
Affinity DataIC50: 5.5nMAssay Description:ASK1 was purchased from Thermofisher, ATP was purchased from Sigma , HTRF KinEASE Assay System was obtained from Cisbio (Bedford, Mass). Area plate w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent