BDBM445666 Ex. 4/KM-06-78/(I-4)::US10683309, Example 4::US11028104, Example 4

SMILES CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(C(=O)OC)cc1

InChI Key InChIKey=YITCJRJDTZUJTI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 445666   

TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445666BDBM445666(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445666BDBM445666(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Affinity DataIC50: 20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445666BDBM445666(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Affinity DataIC50: 20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max Delbruck Center

US Patent
LigandChemical structure of BindingDB Monomer ID 445666BDBM445666(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Affinity DataIC50: 198nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max Delbruck Center

US Patent
LigandChemical structure of BindingDB Monomer ID 445666BDBM445666(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Affinity DataIC50: 198nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent