BDBM446005 US10669246, Example 56::US10968188, Example 56

SMILES Cc1ccsc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1

InChI Key InChIKey=ZOYSLUOCMBWOMR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 446005   

TargetTyrosine-protein kinase ABL1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM446005(US10669246, Example 56 | US10968188, Example 56)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of recombinant human His-tagged c-Abl kinase assessed as luminescence incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM446005(US10669246, Example 56 | US10968188, Example 56)
Affinity DataIC50: 7.90nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM446005(US10669246, Example 56 | US10968188, Example 56)
Affinity DataIC50: 7.90nMAssay Description:c-abl kinase activity was measured by Promega's ADP-Glo Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/μl) is incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent