BDBM446072 2-chloro-6-fluoro-N-{2-[4-(2-fluorophenoxy)piperidin-1-yl]-2-(4- methyl-1,3-thiazol-5-yl)ethyl}benzamide::US10669267, Compound 10

SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1ccccc1F

InChI Key InChIKey=GSYVZCSOIPDPJP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446072   

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM446072(2-chloro-6-fluoro-N-{2-[4-(2-fluorophenoxy)piperid...)
Affinity DataIC50: 42.9nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Axxam

US Patent
LigandPNGBDBM446072(2-chloro-6-fluoro-N-{2-[4-(2-fluorophenoxy)piperid...)
Affinity DataIC50: 583nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent