BDBM446078 N-(2-{4-[(3,4-difluorophenyl)methoxy]piperidin-1-yl}-2-(4- methyl-1,3-thiazol-5-yl)ethyl)quinoline-5-carboxamide::US10669267, Compound 18

SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)OCc1ccc(F)c(F)c1

InChI Key InChIKey=LYZHSHGTPRLRQJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446078   

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM446078(N-(2-{4-[(3,4-difluorophenyl)methoxy]piperidin-1-y...)
Affinity DataIC50: 36.9nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Axxam

US Patent
LigandPNGBDBM446078(N-(2-{4-[(3,4-difluorophenyl)methoxy]piperidin-1-y...)
Affinity DataIC50: 374nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent