BDBM446081 N-{2-[4-(2-fluorophenoxy)piperidin-1-yl]-2-(4-methyl-1,3-thiazol- 5-yl)ethyl}quinoline-5-carboxamide::US10669267, Compound 22

SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccccc1F

InChI Key InChIKey=NXHIMQVODZNZKI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 446081   

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM446081(N-{2-[4-(2-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human P2X7 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM446081(N-{2-[4-(2-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Affinity DataIC50: 30.2nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM446081(N-{2-[4-(2-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Affinity DataIC50: 355nMAssay Description:Inhibition of rat P2X7 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM446081(N-{2-[4-(2-fluorophenoxy)piperidin-1-yl]-2-(4-meth...)
Affinity DataIC50: 355nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent