BDBM446087 N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(2- fluorophenoxy)piperidin-1-yl]ethyl}quinoline-5-carboxamide::US10669267, Compound 37

SMILES FC(F)c1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCC(CC1)Oc1ccccc1F

InChI Key InChIKey=IOWQWGHPVVXWED-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 446087   

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM446087(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(2...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human P2X7 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM446087(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(2...)
Affinity DataIC50: 43.2nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Axxam

US Patent
LigandPNGBDBM446087(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(2...)
Affinity DataIC50: 133nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Axxam

US Patent
LigandPNGBDBM446087(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(2...)
Affinity DataIC50: 133nMAssay Description:Inhibition of rat P2X7 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Axxam

US Patent
LigandPNGBDBM446087(N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-[4-(2...)
Affinity DataIC50: 133nMAssay Description:Ca2+ influx was measured in HEK-293 cells stably transfected with the receptor using Screen Quest Fluo-8 No Wash Calcium Assay Kit (AAt Bioquest ). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent