BDBM446690 US10669289, Compound 97

SMILES OB(O)[C@H](Cc1ccsc1)NC(=O)CN(C(=O)C=C)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=MQXZWONAZRNTFU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446690   

TargetProteasome subunit beta type-8(Human)
Merck Patent

US Patent
LigandPNGBDBM446690(US10669289, Compound 97)
Affinity DataIC50: 50nMAssay Description:Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immuno proteasome (0.25 nM) and s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetProteasome subunit beta type-5(Human)
Merck Patent

US Patent
LigandPNGBDBM446690(US10669289, Compound 97)
Affinity DataIC50: 5.00E+3nMAssay Description:Measurement of Beta5 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human constitutive proteasome (1.25 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent