BDBM447419 (2S,4R)-4-[4-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide::US10689339, Example 27

SMILES Cc1nc(C)n(n1)-c1ccc(c(c1)C(F)(F)F)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)C(F)(F)F)C(=O)NC1(CC1)C#N

InChI Key InChIKey=HASYOHDTEVAWPY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 447419   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM447419(US10689339, Example 27 | (2S,4R)-4-[4-(3,5-Dimethy...)
Affinity DataIC50: 0.558nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent