BDBM447506 US10689357, Example 42

SMILES COc1ccc(nc1)-c1ccc(CO[C@H]2C[C@H](C2)N=C=S)nc1

InChI Key InChIKey=LBBCJWGQDYTJDQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 447506   

TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM447506(US10689357, Example 42)
Affinity DataIC50: 30nMAssay Description:Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM447506(US10689357, Example 42)
Affinity DataIC50: 55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent