BDBM448324 USRE48059, Compound of Example 73::USRE48059, Compound of Example 84

SMILES C(COc1ccc2ncccc2c1)CN1CCN(CC1)c1cccc2sccc12

InChI Key InChIKey=DOLKJSWXNRSFQR-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 448324   

Target5-hydroxytryptamine receptor 2A(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM448324(USRE48059, Compound of Example 73 | USRE48059, Com...)
Affinity DataKi:  1.30nMAssay Description:5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

TargetD(2) dopamine receptor(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM448324(USRE48059, Compound of Example 73 | USRE48059, Com...)
Affinity DataKi:  2.40nMAssay Description:Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM448324(USRE48059, Compound of Example 73 | USRE48059, Com...)
Affinity DataKi:  3.30nMAssay Description:5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

TargetD(2) dopamine receptor(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM448324(USRE48059, Compound of Example 73 | USRE48059, Com...)
Affinity DataKi:  4nMAssay Description:Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent