BDBM448337 USRE48059, Compound of Example 128

SMILES CC(=O)Oc1ccc(CCCN2CCN(CC2)c2cccc3sccc23)c2NC(=O)CCc12

InChI Key InChIKey=RVIHBQPCNYIPAK-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448337   

TargetD(2) dopamine receptor(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM448337(USRE48059, Compound of Example 128)
Affinity DataKi:  1.30nMAssay Description:Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Rat)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM448337(USRE48059, Compound of Example 128)
Affinity DataKi:  6.30nMAssay Description:5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent