BDBM448688 US10695337, Example 254::{1-[1-(methylsulfonyl)piperidin-4-yl]-3-

SMILES CC(C#N)C1(CN(C1)C1CCN(CC1)S(C)(=O)=O)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=PMEYOFBRYPJRFV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448688   

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte Holdings

US Patent
LigandPNGBDBM448688(US10695337, Example 254 | {1-[1-(methylsulfonyl)pi...)
Affinity DataIC50: 5nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte Holdings

US Patent
LigandPNGBDBM448688(US10695337, Example 254 | {1-[1-(methylsulfonyl)pi...)
Affinity DataIC50: 30nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent