BDBM448735 (S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)methyl)phenyl)ethyl) amino)pyrimidin-4-yl)- 4-methyloxazolidin-2-one::US10696665, Example 3

SMILES C[C@H](Nc1nccc(n1)N1[C@@H](C)COC1=O)c1ccc(CN2CCN(CC2)C(=O)C=C)cc1

InChI Key InChIKey=OOHVXQVMMPWTKY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 448735   

LigandPNGBDBM448735((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 210nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandPNGBDBM448735((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 246nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Eli Lilly

US Patent
LigandPNGBDBM448735((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 1.55E+4nMAssay Description:Wild-Type IDH1: Enzymes catalyze the conversion of isocitrate to αKG. Wild-type IDH1 (National Center for Biotechnology Information, Accession: ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent