BDBM448740 (S)-3-(2-((1-(4-((4- acryloylpiperazin-1- yl)methyl)phenyl)ethyl) amino)-5-fluoropyrimidin- 4-yl)-4,4- dimethyloxazolidin-2-one::US10696665, Example 8

SMILES C[C@H](Nc1ncc(F)c(n1)N1C(=O)OCC1(C)C)c1ccc(CN2CCN(CC2)C(=O)C=C)cc1

InChI Key InChIKey=FUDYXUKVOLBVPN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 448740   

LigandPNGBDBM448740((S)-3-(2-((1-(4-((4- acryloylpiperazin-1- yl)methy...)
Affinity DataIC50: 250nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM448740((S)-3-(2-((1-(4-((4- acryloylpiperazin-1- yl)methy...)
Affinity DataIC50: 250nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandPNGBDBM448740((S)-3-(2-((1-(4-((4- acryloylpiperazin-1- yl)methy...)
Affinity DataIC50: 495nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandPNGBDBM448740((S)-3-(2-((1-(4-((4- acryloylpiperazin-1- yl)methy...)
Affinity DataIC50: 495nMAssay Description:Inhibition of human recombinant IDH1 R132H mutant expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed