BDBM448741 (S)-3-(2-(1-(4-((4- acryloylpiperazin-1- yl)methyl)phenyl)-2- fluoroethyl)amino)pyrimidin- 4-yl)-4-ethyloxazolidin- 2-one, isomer 2::US10696665, Example 9

SMILES CC[C@H]1COC(=O)N1c1ccnc(NC(CF)c2ccc(CN3CCN(CC3)C(=O)C=C)cc2)n1

InChI Key InChIKey=NNDBRWCKZTXFOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448741   

LigandPNGBDBM448741((S)-3-(2-(1-(4-((4- acryloylpiperazin-1- yl)methyl...)
Affinity DataIC50: 101nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandPNGBDBM448741((S)-3-(2-(1-(4-((4- acryloylpiperazin-1- yl)methyl...)
Affinity DataIC50: 176nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent