BDBM448748 3-(2-(((1S)-1-(4-(1-(4- acryloylpiperazin-1- yl)propyl)phenyl)ethyl)amino) pyrimidin-4-yl)oxazolidin-2-one, isomer 1::US10696665, Example 16::US10696665, Example 17

SMILES CCC(N1CCN(CC1)C(=O)C=C)c1ccc(cc1)[C@H](C)Nc1nccc(n1)N1CCOC1=O

InChI Key InChIKey=VLZWVMXOKOOBSV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 448748   

LigandPNGBDBM448748(US10696665, Example 17 | 3-(2-(((1S)-1-(4-(1-(4- a...)
Affinity DataIC50: 125nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandPNGBDBM448748(US10696665, Example 17 | 3-(2-(((1S)-1-(4-(1-(4- a...)
Affinity DataIC50: 273nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandPNGBDBM448748(US10696665, Example 17 | 3-(2-(((1S)-1-(4-(1-(4- a...)
Affinity DataIC50: 273nMAssay Description:Inhibition of human recombinant IDH1 R132H mutant expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM448748(US10696665, Example 17 | 3-(2-(((1S)-1-(4-(1-(4- a...)
Affinity DataIC50: 291nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandPNGBDBM448748(US10696665, Example 17 | 3-(2-(((1S)-1-(4-(1-(4- a...)
Affinity DataIC50: 568nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM448748(US10696665, Example 17 | 3-(2-(((1S)-1-(4-(1-(4- a...)
Affinity DataIC50: 586nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent