BDBM448922 5-Fluoro-4-(4-fluoro-7,8,9,10-tetrahydro-6H-benzo[4,5]imidazo[1,2-a]azepan-2-yl)-N-(5-(piperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine::US10696678, Example 17

SMILES Fc1cnc(Nc2ccc(cn2)N2CCNCC2)nc1-c1cc(F)c2nc3CCCCCn3c2c1

InChI Key InChIKey=SXZNWPVWRGMGBV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 448922   

TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448922(5-Fluoro-4-(4-fluoro-7,8,9,10-tetrahydro-6H-benzo[...)
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448922(5-Fluoro-4-(4-fluoro-7,8,9,10-tetrahydro-6H-benzo[...)
Affinity DataIC50: 1.90E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448922(5-Fluoro-4-(4-fluoro-7,8,9,10-tetrahydro-6H-benzo[...)
Affinity DataIC50: 2.36E+5nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent