BDBM448930 4-(1,1-Dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-5-fluoro-N-(5-(piperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine::US10696678, Example 25

SMILES CC1(C)CCc2nc3ccc(cc3n12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F

InChI Key InChIKey=VZOSIDLADHATGZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 448930   

TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448930(4-(1,1-Dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2...)
Affinity DataIC50: 109nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448930(4-(1,1-Dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2...)
Affinity DataIC50: 600nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448930(4-(1,1-Dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2...)
Affinity DataIC50: 2.80E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent