BDBM448946 5-Fluoro-4-(5-fluoro-1-methyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(6-methyl-5-(4-methylpiperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine::US10696678, Example 41

SMILES CC1CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(N3CCN(C)CC3)c(C)n2)ncc1F

InChI Key InChIKey=NANKOADZZHRGFX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 448946   

TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448946(5-Fluoro-4-(5-fluoro-1-methyl-2,3-dihydro-1H-benzo...)
Affinity DataIC50: 1.73E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448946(5-Fluoro-4-(5-fluoro-1-methyl-2,3-dihydro-1H-benzo...)
Affinity DataIC50: 2.85E+4nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448946(5-Fluoro-4-(5-fluoro-1-methyl-2,3-dihydro-1H-benzo...)
Affinity DataIC50: 5.78E+4nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent