BDBM449086 Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-[1- (2,2,2-trifluoro-ethyl)- piperidine-4-sulfonyl]- benzylamide::US10696692, Example 209::US10696692, Example 64

SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1

InChI Key InChIKey=VAWXYQZQKQDFGN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 449086   

TargetNicotinamide phosphoribosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM449086(US10696692, Example 209 | Imidazo[1,2-a]pyrimidine...)
Affinity DataIC50: 3.70nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM449086(US10696692, Example 209 | Imidazo[1,2-a]pyrimidine...)
Affinity DataIC50: 3.72nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent