BDBM449095 US10696692, Example 73::US10696692, Example 74::cis-Imidazo[1,2- a]pyridine-6-carboxylic acid 4-(4,4-difluoro- hexahydro- cyclopenta[c]pyrrole-2- sulfonyl)-benzylamide (isomer A)

SMILES FC1(F)CCC2CN(CC12)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1

InChI Key InChIKey=SXRRUZRQRAQCEK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 449095   

TargetNicotinamide phosphoribosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM449095(US10696692, Example 74 | cis-Imidazo[1,2- a]pyridi...)
Affinity DataIC50: 3nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM449095(US10696692, Example 74 | cis-Imidazo[1,2- a]pyridi...)
Affinity DataIC50: 5nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent