BDBM449200 Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4-(1- isobutyl-piperidine-4- sulfinyl)-benzylamide (racemic)::US10696692, Example 179::US10696692, Example 188

SMILES CC(C)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)cc1

InChI Key InChIKey=CZXIKVGYRJBRFB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 449200   

TargetNicotinamide phosphoribosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM449200(US10696692, Example 179 | Imidazo[1,2-a]pyrimidine...)
Affinity DataIC50: 7.60nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM449200(US10696692, Example 179 | Imidazo[1,2-a]pyrimidine...)
Affinity DataIC50: 7.70nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent